GnRH Receptor Antagonist Mono- And Combination Therapy With E2/NETA Add-Back – Pharmacodynamics And Safety Of OBE2109

December 4, 2017

Linzagolix

Pohl O, Marchand L, Fawkes N, Gotteland JP, Loumaye E.

Pohl O, Marchand L, Fawkes N, Gotteland JP, Loumaye E. Gonadotropin-Releasing Hormone Receptor Antagonist Mono- and Combination Therapy With Estradiol/Norethindrone Acetate Add-Back: Pharmacodynamics and Safety of OBE2109. J Clin Endocrinol Metab. 2018;103(2):497‐504. doi:10.1210/jc.2017-01875

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Confirmation of the Cardiac Safety of OBE022 in a First in Human Study in Healthy Subjects using Intensive ECG Assessments and the Effect of a Meal on QTc to Show Assay Sensitivity

September 19, 2017

OBE022

J. Täubel, U. Lorch , G. Ferber , O Pohl

ACCP Conference, 17-19 September 2017, San Diego, CA
Poster 019: Page 16

Volume6, IssueS1, Special Issue: 2017 Annual Meeting American College of Clinical Pharmacology, September 2017, doi:full/10.1002/cpdd.385

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A placebo-controlled, randomized, double-blind study of pregnancy and live birth rates after single oral administration of a novel oxytocin antagonist, nolasiban, prior to embryo transfer

July 5, 2017

Nolasiban

H. Tournaye, A. Humberstone, V. Lecomte, P. Terrill, P. Pierzynski, E. Loumaye

ESHRE 33rd Annual Meeting, 2-5 July 2017, Geneva, Switzerland
Abstract O-024: Page i12

Abstracts of the 33rd Annual Meeting of the European Society of Human Reproduction and Embryology, Human Reproduction, Volume 32, Issue suppl_1, July 2017, Pages i1–i539

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Combination tocolytics on the inhibition of OT-induced contractions of human pregnant myometrium in vitro

Nolasiban

L. Riaposova, S.H. Kim, O. Pohl, A. Chollet, J.P. Gotteland, A. Hanyaloglu, P. Bennett, V. Terzidou

ESHRE 33rd Annual Meeting, 2-5 July 2017, Geneva, Switzerland
Abstract O-119: Page i54

Abstracts of the 33rd Annual Meeting of the European Society of Human Reproduction and Embryology, Human Reproduction, Volume 32, Issue suppl_1, July 2017, Pages i1–i539

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FP receptor antagonist, OBE002, inhibits both PGF2α- and OT-induced contractions of human pregnant myometrium in vitro

OBE022

L. Riaposova, S.H. Kim, O. Pohl, A. Chollet, J.P. Gotteland, A. Hanyaloglu, P. Bennett, V. Terzidou

ESHRE 33rd Annual Meeting, 2-5 July 2017, Geneva, Switzerland
Abstract P-692: Page i452

Abstracts of the 33rd Annual Meeting of the European Society of Human Reproduction and Embryology, Human Reproduction, Volume 32, Issue suppl_1, July 2017, Pages i1–i539

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Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor–Mediated Signaling in Human Amnion and Myometrium

April 1, 2017

Nolasiban

Sung Hye Kim, Oliver Pohl, Andre Chollet, Jean-Pierre Gotteland, Adam D. J. Fairhurst, Phillip R. Bennett, and Vasso Terzidou

Kim SH, Pohl O, Chollet A, et al. Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor-Mediated Signaling in Human Amnion and Myometrium. Mol Pharmacol. 2017;91(4):403‐415. doi:10.1124/mol.116.106013

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THE ‘ART’ OF WOMEN’S HEALTH – Add back or not add back? Obseva: Both options good as UF, endo trials continue

March 30, 2017

Linzagolix

THE ‘ART’ OF WOMEN’S HEALTH – Add back or not add back? Obseva: Both options good as UF, endo trials…

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Both OTR Antagonists, Atosiban and Nolasiban, Inhibits PGE2/PGF2α-Induced Contractions of Human Pregnant Myometrium In Vitro

March 18, 2017

Nolasiban

Sung Hye Kim, Hauwa Ahmed, Lucia Riaposova, Oliver Pohl, Andre Chollet, Aylin Hanyaloglu, Phillip R Bennett, Vasso Terzidou

SRI Conference, 15-18 March 2017, Orlando, FL
Abstract S-031: Page 245A

Scientific Abstracts Reproductive Sciences Vol. 24 (1_suppl), 1A-51A, March 2017

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The OTR Antagonist, OBE001, Inhibits Both Spontaneous and OT-Induced Contractions of Human Pregnant Myometrium In Vitro

March 16, 2016

Nolasiban

Shankari Arulkumaran, Sung Hye Kim, Oliver Pohl, Andre Chollet, Phillip R. Bennett and Vasso Terzidou

SRI Conference, 16-19 March 2016, Montreal, Canada
Abstract S-096

Scientific Abstracts. (2016). Reproductive Sciences, 23(1_suppl), 51A-344A

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The OTR Antagonist, OBE001, Inhibits OT-Driven Proinflammatory Effects in Both Human Myometrium and Amnion

Nolasiban

Sung Hye Kim, Oliver Pohl, Andre Chollet, Adam Fairhurst, Phillip R Bennett, Vasso Terzidou

SRI Conference, 16-19 March 2016, Montreal, Canada
Abstract T-071: Page 123A

Scientific Abstracts. (2016). Reproductive Sciences, 23(1_suppl), 51A-344A

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