ObsEva

08 Apr 2019

Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F2α-induced Contractions and Inflammatory Responses in Human Myometrium

Sung Hye Kim, Lucia Riaposova, Hauwa Ahmed, Oliver Pohl, André Chollet, Jean-Pierre Gotteland, Aylin Hanyaloglu, Phillip R. Bennett & Vasso Terzidou

www.nature.com/scientificreports

09 Oct 2018

A Placebo-Controlled, Randomized, Double-Blind, Phase 3 Study Assessing Ongoing Pregnancy Rates After Single Oral Administration of a Novel Oxytocin Receptor Antagonist, Nolasiban, Prior to Single Embryo Transfer

Visnova H., Tournaye H. J., Humberstone A., Terrill P., Macgregor L., Loumaye E.

ASRM 2018, 6-10 October 2018, Denver, CO

04 Jul 2018

Effects of the oral oxytocin receptor antagonist nolasiban on early embryonic development

O. Pohl, D. Perks, R. Sisti, J.P. Gotteland

ESHRE Annual Conference, 01-04 July 2018, Barcelona, Spain

24 Apr 2018

ObsEva on page 17 of Understanding Fertility Special Report 2018

Special report in the Raconteur Article in 'The Times'

Click here for publication link

IVF ‘BREAKTHROUGH’ TREATMENT

Pioneering use of the first oral medication of its kind in IVF treatment is showing remarkable trial results

05 Jul 2017

A placebo-controlled, randomized, double-blind study of pregnancy and live birth rates after single oral administration of a novel oxytocin antagonist, nolasiban, prior to embryo transfer

H. Tournaye, A. Humberstone, V. Lecomte, P. Terrill, P. Pierzynski, E. Loumaye

ESHRE 33rd Annual Meeting, 2-5 July 2017, Geneva, Switzerland

01 Apr 2017

Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor–Mediated Signaling in Human Amnion and Myometrium

Sung Hye Kim, Oliver Pohl, Andre Chollet, Jean-Pierre Gotteland, Adam D. J. Fairhurst, Phillip R. Bennett, and Vasso Terzidou

Mol Pharmacol. 2017 Apr; 91(4): 403–415.

18 Mar 2017

Both OTR Antagonists, Atosiban and Nolasiban, Inhibits PGE2/PGF2α-Induced Contractions of Human Pregnant Myometrium In Vitro.

Sung Hye Kim, Hauwa Ahmed, Lucia Riaposova, Oliver Pohl, Andre Chollet, Aylin Hanyaloglu, Phillip R Bennett, Vasso Terzidou

SRI Conference, 15-18 March 2017, Orlando, FL

16 Mar 2016

The OTR Antagonist, OBE001, Inhibits Both Spontaneous and OT-Induced Contractions of Human Pregnant Myometrium In Vitro.

Shankari Arulkumaran, Sung Hye Kim, Oliver Pohl, Andre Chollet, Phillip R. Bennett and Vasso Terzidou

SRI Conference, 16-19 March 2016, Montreal, CANADA

16 Mar 2016

The OTR Antagonist, OBE001, Inhibits OT-Driven Proinflammatory Effects in Both Human Myometrium and Amnion.

Sung Hye Kim, Oliver Pohl, Andre Chollet, Adam Fairhurst, Phillip R Bennett, Vasso Terzidou

SRI Conference, 16-19 March 2016, Montreal, CANADA

16 Mar 2016

The OTR Antagonist, OBE001, Suppresses the Effects of OT on miRNA Expression in Human Myometrium.

Sung Hye Kim, Stacey Robinson, Joanna Cook, Oliver Pohl, Andre Chollet, Phillip R Bennett, Vasso Terzidou.

SRI Conference, 16-19 March 2016, Montreal, CANADA

Our Pipeline

Oxytocin Receptor Antagonists, Atosiban and Nolasiban, Inhibit Prostaglandin F2α-induced Contractions and Inflammatory Responses in Human Myometrium

A Placebo-Controlled, Randomized, Double-Blind, Phase 3 Study Assessing Ongoing Pregnancy Rates After Single Oral Administration of a Novel Oxytocin Receptor Antagonist, Nolasiban, Prior to Single Embryo Transfer

Effects of the oral oxytocin receptor antagonist nolasiban on early embryonic development

ObsEva on page 17 of Understanding Fertility Special Report 2018

A placebo-controlled, randomized, double-blind study of pregnancy and live birth rates after single oral administration of a novel oxytocin antagonist, nolasiban, prior to embryo transfer

Differential Effects of Oxytocin Receptor Antagonists, Atosiban and Nolasiban, on Oxytocin Receptor–Mediated Signaling in Human Amnion and Myometrium

Both OTR Antagonists, Atosiban and Nolasiban, Inhibits PGE2/PGF2α-Induced Contractions of Human Pregnant Myometrium In Vitro.

The OTR Antagonist, OBE001, Inhibits Both Spontaneous and OT-Induced Contractions of Human Pregnant Myometrium In Vitro.

The OTR Antagonist, OBE001, Inhibits OT-Driven Proinflammatory Effects in Both Human Myometrium and Amnion.

The OTR Antagonist, OBE001, Suppresses the Effects of OT on miRNA Expression in Human Myometrium.

Media Contact